Journal
MEDCHEMCOMM
Volume 4, Issue 3, Pages 559-563Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3md20359j
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Neutral, non- or not easily-ionizable active pharmaceutical ingredients can take advantage of the unique property sets of ionic liquids by functionalization with hydrolyzable, charged (or ionizable) groups in the preparation of ionic liquid prodrugs as demonstrated here with the synthesis, characterization, and hydrolysis of cationic acetaminophen prodrugs paired with the docusate anion.
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