4.1 Article

Synthesis and biological activities of ferrocenyl derivatives of paclitaxel

Journal

MEDCHEMCOMM
Volume 3, Issue 4, Pages 498-501

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2md00315e

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Funding

  1. Polish Ministry of Science and Higher Education
  2. European Commission [NMP4-CT-2006-026668]

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A series of ferrocenyl taxoids were prepared by acylation of paclitaxel and docetaxel with ferrocenecarboxylic acid and 3-ferrocenoylpropionic acid in good yield. The prepared compounds showed high activities against multidrug-resistant colon adenocarcinoma cell lines.

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