4.1 Article

A second generation MRI contrast agent for imaging zinc ions in vivo

Journal

MEDCHEMCOMM
Volume 3, Issue 4, Pages 480-483

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2md00301e

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Funding

  1. Universidad de Guanajuato (DAIP) [000024/10]
  2. SEP [UGTO-CA-107]
  3. National Institutes of Health, USA [DK-058398, RR-02584]
  4. Robert A. Welch Foundation [AT-584]

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A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.

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