Journal
MEDCHEMCOMM
Volume 3, Issue 8, Pages 976-981Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2md20024d
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Funding
- University of Wisconsin-Milwaukee
- NIH/NCI [R01 CA152212]
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Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A (1), B (2) and C (3), were discovered from the culture broth of Burkholderia thailandensis E264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D (4), E (5) and F (6), respectively. Enzyme assays showed that 1-6 are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents class I human HDACs.
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