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Minisci reactions: Versatile CH-functionalizations for medicinal chemists

Journal

MEDCHEMCOMM
Volume 2, Issue 12, Pages 1135-1161

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00134e

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The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici reaction. Such reactions constitute a broad-set of selective CH-functionalization processes. This review describes some of the major applications of Minisci reactions and related processes to medicinal or biological chemistry, and highlights some potential developments within this area.

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