Journal
MEDCHEMCOMM
Volume 2, Issue 7, Pages 666-668Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00075f
Keywords
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Funding
- EPSRC (Knowledge Transfer Network)
- European Research Council [247450]
- Science City/EU ERDF/AWM
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This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF6, is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.
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