Journal
MEDCHEMCOMM
Volume 2, Issue 7, Pages 666-668Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00075f
Keywords
-
Funding
- EPSRC (Knowledge Transfer Network)
- European Research Council [247450]
- Science City/EU ERDF/AWM
Ask authors/readers for more resources
This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(eta(6)-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF6, is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available