Journal
MEDCHEMCOMM
Volume 2, Issue 7, Pages 626-630Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0md00239a
Keywords
-
Funding
- MICINN, Spain
- Department of Science and Technology, New Delhi [DST/INT/SPAIN/09, ACI2009-0956]
- DST
- MICINN [CTQ2009-12320-BQU]
- University Grants Commission, New Delhi
Ask authors/readers for more resources
Spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrid compounds were obtained in excellent yields from the regio- and stereoselective reaction between beta-nitrostyrenes and non-stabilized azomethine ylides, generated in situ from isatin and phenylglycine/proline/thiaproline. These compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB). Eleven compounds were more active than pyrazinamide and one of them, namely 6'-(3-nitrophenyl)-7'-nitro-3',6',7',7a'-tetrahydro-1'H-spiro-[indoline-3,5'-pyrrolo-[1,2-c]thiazol]-2-one, displayed a 7.6 mu M MIC value, which represents a potency similar to that of the first-line anti-TB drug ethambutol and 6.7 times higher than that of pyrazinamide.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available