4.1 Article

Novel N-sulfonamide trans-platinum complexes: synthesis, reactivity and in vitro evaluation

Journal

MEDCHEMCOMM
Volume 2, Issue 8, Pages 789-793

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00070e

Keywords

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Funding

  1. Spanish MEC [SAF2009-09431]
  2. Spanish MICINN [CTQ2008-06806-C02-01/BQU]
  3. Spanish MSC [RTICC RD06/0020/1046]
  4. Canary Islands ACIISI [PI2007/021]
  5. Canary Islands FUNCIS [PT 35/06, 43/09]
  6. Spanish MICINN for Ramon y Cajal

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In this work, we described for the first time the synthesis of trans-N-sulfonamide platinum complexes. The antiproliferative activity (GI(50), mu M) of these new compounds in human solid tumors cells was compared to cisplatin.

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