Journal
MEDCHEMCOMM
Volume 2, Issue 7, Pages 611-615Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1md00023c
Keywords
-
Funding
- Cancer Research UK [6950] Funding Source: researchfish
Ask authors/readers for more resources
The human deacetylase SIRT2 is believed to promote neurodegeneration with recent studies demonstrating that a reduction in the activity of SIRT2 can rescue alpha synuclein toxicity in Parkinson's disease models. In contrast, a second member of the sirtuin family, SIRT1, is believed to play a neuroprotective role. This dichotomy places an additional challenge in the path of sirtuin inhibitor development as a need for isozyme selectivity arises. By combining computational methods with assessment of the biological activity of novel N1-substituted cambinol analogues, further insights that are relevant to this challenge are obtained.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available