Journal
MEDCHEMCOMM
Volume 2, Issue 5, Pages 378-384Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0md00246a
Keywords
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Funding
- UGC
- CSIR New Delhi
- DRDO
- DBT New Delhi
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A series of dispiro-cycloalkanones were synthesized using the Corey Chaykovsky reaction of alpha,alpha'-(E,E)-bis(benzylidene)-cycloalkanones/methanone in good yields. The compounds were evaluated for their in vitro antituberculosis activity against M. tuberculosis H37Rv and screened in silico. Some selected compounds were screened for mycobacterial NAD(+)-dependent DNA ligase inhibitory activity. Two of the compounds showed good in vitro antitubercular and NAD(+)-dependent DNA ligase inhibitory activity along with good correlation to in silico results.
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