Journal
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
Volume 188, Issue -, Pages 82-85Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autneu.2014.10.017
Keywords
Demyelination; Cardiovascular; Blood pressure; Thermoregulation; Sweat; Sympathetic nerve activity
Categories
Funding
- National Heart, Lung, and Blood Institute [R15HL117224]
- National Multiple Sclerosis Society [RG4696A3/2, PP1440]
- William C. Kuzell Award from the Kuzell Institute
Ask authors/readers for more resources
Multiple sclerosis (MS), a progressive neurological disease, can result in autonomic dysfunction. Impairments in the autonomic control of cardiovascular and thermoregulatory function during exercise have been observed in MS. Attenuated elevations in blood pressure during exercise in MS patients can negatively impact blood flow to skeletal muscle. Diminished sweating during exercise may impair heat dissipation likely limiting the exercise intensity that can be performed before detrimental core temperatures are reached. Further understanding the physiologic mechanisms of autonomic dysfunction during exercise in MS may lead to the development of novel therapeutic strategies targeted at improving quality of life in individuals with this disease. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available