Journal
BIOANALYSIS
Volume 5, Issue 22, Pages 2821-2836Publisher
FUTURE SCI LTD
DOI: 10.4155/bio.13.243
Keywords
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Funding
- National Institute of Allergy and Infectious Disease of the NIH [R01AI096184]
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This Review focuses on recent work in the field of paper microfluidics that specifically addresses the goal of translating the multistep processes that are characteristic of gold-standard laboratory tests to low-resource point-of-care settings. A major challenge is to implement multistep processes with the robust fluid control required to achieve the necessary sensitivity and specificity of a given application in a user-friendly package that minimizes equipment. We review key work in the areas of fluidic controls for automation in paper-based devices, readout methods that minimize dedicated equipment, and power and heating methods that are compatible with low-resource point-of-care settings. We also highlight a focused set of recent applications and discuss future challenges.
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