Journal
BIOANALYSIS
Volume 4, Issue 10, Pages 1205-1213Publisher
FUTURE SCI LTD
DOI: 10.4155/BIO.12.81
Keywords
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Funding
- National Natural Science Foundation of China [30873428]
- Science and Technology Ministry of China [2009ZX09304-003]
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Background: Dahuang Huanglian Xiexin Decoction (DHXD) is a classical formula in traditional Chinese medicines. In this study, a novel UPLC-MS/MS method was developed for the simultaneous quantification of rhein, emodin, berberine and baicalin, the major bioactive compounds of DHXD in rat plasma. Results: The method possessed high sensitivity and ultrashort analysis time (7 min). Linearity, accuracy, precision and extraction recovery of four analytes were all satisfactory. The method was then successfully applied in a pharmacokinetic study of four bioactive components after a single oral administration of DHXD extract to rats. Conclusion: The method was applicable for simultaneous bioanalysis of rhein, emodin, berberine and baicalin.
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