Journal
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncom.2014.00089
Keywords
plateau potentials; dendrites; spike timing; inhibition; non-linear dendrites
Funding
- NINDS [NS 074015]
- Swiss National Science Foundation [PA00P3_131470]
- G. Harold and Leila Y. Mathers Charitable Foundation
- Human Frontiers Science Program [RGP0032/2011]
- Whitaker International Program
- National Science Foundation
- Swiss National Science Foundation (SNF) [PA00P3_131470] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Apical and tuft dendrites of pyramidal neurons support regenerative electrical potentials, giving rise to long-lasting (approximately hundreds of milliseconds) and strong (similar to 50 mV from rest) depolarizations. Such plateau events rely on clustered glutamatergic input, can be mediated by calcium or by NMDA currents, and often generate somatic depolarizations that last for the time course of the dendritic plateau event. We address the computational significance of such single-neuron processing via reduced but biophysically realistic modeling. We introduce a model based on two discrete integration zones, a somatic and a dendritic one, that communicate from the dendritic to the somatic compartment via a long plateau-conductance. We show principled differences in the way dendritic vs. somatic inhibition controls spike timing, and demonstrate how this could implement spike time control in the face of barrages of synaptic inputs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available