Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 5, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fncel.2011.00029
Keywords
Down syndrome; Ts65Dn mice; environmental enrichment; GABAergic inhibition; cerebral plasticity
Categories
Funding
- Regione Toscana
- Fondazione Cassadi Risparmio di Pisa
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Down syndrome (DS) is the most common genetic disorder associated with mental retardation. It has been repeatedly shown that Ts65Dn mice, the prime animal model for DS, have severe cognitive and neural plasticity defects due to excessive inhibition. We report that increasing sensory-motor stimulation in adulthood through environmental enrichment (EE) reduces brain inhibition levels and promotes recovery of spatial memory abilities, hippocampal synaptic plasticity, and visual functions in adult Ts65Dn mice.
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