Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/neuro.03.005.2009
Keywords
optical imaging; cerebellum; calcium probes; voltage probes; genetically encoded probes
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Funding
- Knopfel laboratory
- RIKEN BSI
- NIH under Yale University [NS057631]
- JSPS (Japanese Society for the Promotion of Science)
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The relatively simple and highly modular circuitry of the cerebellum raised expectations decades ago that a realistic computational model of cerebellar circuit operations would be feasible, and prove insightful for unraveling cerebellar information processing. To this end, the biophysical properties of most cerebellar cell types and their synaptic connections have been well characterized and integrated into realistic single cell models. Furthermore, large scale models of cerebellar circuits that extrapolate from single cell properties to circuit dynamics have been constructed. While the development of single cell models have been constrained by microelectrode recordings, guidance and validation as these models are scaled up to study network interactions requires an experimental methodology capable of monitoring cerebellar dynamics at the population level. Here we review the potential of optical imaging techniques to serve this purpose.
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