Journal
INTERNATIONAL WOUND JOURNAL
Volume 5, Issue 3, Pages 435-444Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1742-481X.2007.00360.x
Keywords
Adrenergic receptors; Amino acid; Anticoagulant; Blood pressure; Collagen; Collagen synthesis; Fibronectin; Glycosaminoglycans; Pressure ulcers; Spinal cord injury; Transcutaneous oxygen; Wound healing
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There are many metabolic and physiological changes that happen to the tissues below the level of a spinal cord injury. These deficits are examined in relation to the series of events that has to take place for wound healing - the wound healing cascade. The conclusion is that every step of the wound healing process is impaired by the physiological deficits inherent post-spinal cord injury. This may explain, in part, why pressure ulcers on these patients are so difficult to close and to maintain closed.
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