Journal
INTERNATIONAL BRAZ J UROL
Volume 36, Issue 3, Pages 273-282Publisher
BRAZILIAN SOC UROL
DOI: 10.1590/S1677-55382010000300003
Keywords
bladder neoplasms; drug therapy; vascular endothelial growth factors; epidermal growth factors; fibroblast growth factors
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Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease. The high frequency of recurrence of noninvasive bladder cancer and poor survival rate of invasive bladder cancer emphasizes the need for novel therapeutic approaches. These mechanisms of tumor development and promotion in bladder cancer are strongly associated with several growth factor pathways including the fibroblast, epidermal, and the vascular endothelial growth factor pathways. In this review, efforts to translate the growing body of basic science research of novel treatments into clinical applications will be explored.
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