Journal
PAIN RESEARCH & MANAGEMENT
Volume 14, Issue 4, Pages 275-282Publisher
HINDAWI LTD
DOI: 10.1155/2009/380384
Keywords
Herpes zoster; Neuropathic pain; Postherpetic neuralgia; Varicella
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Funding
- Merck Frosst Canada, Ltd
- Allon Therapeutics (Canada)
- Endo Pharmaceuticals (USA)
- Johnson Johnson (USA)
- KAI Pharmaceuticals (USA)
- WEX Pharmaceuticals (Canada)
- Xanodyne Pharmaceuticals (USA)
- Trophos SA (France)
- Purdue
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OBJECTIVES: The history behind the current understanding of the varicella-zoster virus and its relationship to the pain conditions caused by shingles and postherpetic neuralgia are reviewed. The framework for the current conceptualization is Hope-Simpson's latency hypothesis. Data from recent work in virology, neuroanatomy and epidemiology are reviewed, as is work using varicella-zoster virus-infected animals. The recent data largely confirm Hope-Simpson's hypothesis and extend it significantly.
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