Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 1, Pages 39-44Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01533a
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Funding
- Ministry of Science and Technology of China [2011CB606202]
- Ministry of Education of China [20120141130003]
- Natural Science Foundation of Hubei Province of China [2013CFA003]
- Fundamental Research Fund for the Central Universities of China
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In this paper, an intracellular glutathione (GSH) responsive mesoporous silica nanoparticle (MSN-S-S-RGD) was developed as a drug nanocarrier by immobilizing the gatekeeper (RGD containing peptide) onto MSNs using disulfide bonds. The antitumor drug, DOX was loaded onto the porous structure of the MSNs and the DOX@MSN-S-S-RGD system has been proved to be an effective nanocarrier. It was determined that most of the drug could be entrapped with only a slight leakage. After being accumulated in tumor cells via the receptor-mediated endocytosis, the surface peptide layer of DOX@MSN-S-S-RGD was removed to trigger the release of the entrapped drug to kill the tumor cell due to the cleavage of the disulfide bonds by intracellular GSH.
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