4.2 Article

Copper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions

Journal

JOURNAL OF CHEMICAL RESEARCH
Volume -, Issue 3, Pages 180-182

Publisher

SCIENCE REVIEWS 2000 LTD
DOI: 10.3184/174751914X13922969308054

Keywords

copper; ligand-free; N-arylation; pyrrole; aryl iodides

Funding

  1. Outstanding Youth Project of Shihezi University [2012ZRKXYQ-YD02]
  2. Opening Project of the Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan [KF201303]
  3. Ministry of Education Innovation Team [IRT1161]

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A simple, inexpensive and ligand-free copper-catalysed N-arylation of pyrrole with aryl iodides has been developed giving N-arylated products in moderate to excellent yields. The catalyst loading is relative low (5 mol%) and the catalyst system was stable in air.

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