Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 20, Pages 4105-4117Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00393h
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Funding
- University of Wollongong (UOW)
- Australian Research Council (ARC) through its Centre of Excellence and Future Fellowship programs
- Australian National Fabrication Facility (ANFF)
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This review evaluates hydrogel-forming polymers that are suitable for soft tissue engineering with a focus on materials that can be fabricated using additive manufacturing (3D-printing). An overview of the specific material requirements for hydrogel-based tissue engineering constructs is presented. This is followed by an explanation of the various hydrogel-forming polymer classes that includes a detailed examination of material properties that are critical for extrusion printing. Specifically, mechanisms for hydrogel formation, degradation, and biological response, activity and compatibility are explored. A discussion of extrusion printing strategies for printable hydrogel-forming polymers is then presented in conjunction with a list of considerations to guide future tissue engineering developments.
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