4.6 Article

In vivo multi-photon luminescence imaging of cerebral vasculature and blood-brain barrier integrity using gold nanoparticles

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 15, Pages 2935-2938

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01759e

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Funding

  1. National Research Foundation of Korea (NRF) - Ministry of Science, ICT and Future Planning [NRF-2012R1A1A1011058]
  2. National R&D Program for Cancer Control of the Ministry for Health and Welfare [1220070]
  3. KUSTAR-KAIST Institute at KAIST, Republic of Korea

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We report that time-dependent morphological changes of cortical vasculature, which would be associated with blood-brain barrier disruption, can be clearly visualized with high spatial resolution in a stroke mouse model using the multi-photon luminescence of long-circulating gold nanoparticles.

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