4.2 Article

The first total synthesis of fuscain

Journal

JOURNAL OF CHEMICAL RESEARCH
Volume -, Issue 12, Pages 736-737

Publisher

SCIENCE REVIEWS 2000 LTD
DOI: 10.3184/174751912X13528167435099

Keywords

fuscain; furanolactam; total synthesis; seven-membered ring; mild Lewis acid

Funding

  1. National Natural Science Foundation of China [21172094]
  2. Guangdong Scientific Research Program Foundation [211A080504007]

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The first total synthesis of the furanolactam fuscain is reported. The key step in the synthesis was the formation of seven-membered lactam by acylation of a furan ring using the mild Lewis acid CuSO4 center dot 5H(2)O.

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