Journal
JOURNAL OF CHEMICAL RESEARCH
Volume -, Issue 1, Pages 22-23Publisher
SAGE PUBLICATIONS LTD
DOI: 10.3184/030823409X393664
Keywords
corticosteroids; 17-ketosteroids; molecular iodine; cleavage reaction
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Funding
- Natural Science Foundation of Jiangsu Education Ministry of China [07KJB150135]
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A convenient approach to 17-ketosteroids by the iodine-promoted cleavage of the C-17-dihydroxy acetone side chain of corticosteroids is described. Treatment of steroids containing the C-17-dihydroxyacetone side chain with iodine and an excess of aqueous ammonia in acetonitrile at 50 degrees C, affords high yields of the corresponding 17-ketosteroids.
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