Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 37, Pages 7372-7376Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00766f
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Funding
- NIH [1DP2EB016572]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [DP2EB016572] Funding Source: NIH RePORTER
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A challenge of X-ray radiation therapy is that high dose X-ray can damage normal cells and cause side effects. This paper describes a new nanoparticle-based method to reduce X-ray dose in radiation therapy by internalization of gold nanoparticles that are modified with cationic molecules into cancer cells. A cationic thiol molecule is synthesized and used to modify gold nanoparticles in a one-step reaction. The modified nanoparticles can penetrate cell membranes at high yield. By bringing radio-sensitized gold nanoparticles closer to nuclei where DNA is stored, the total X-ray dose needed to kill cancer cells has been reduced. The simulation of X-ray-gold nanoparticle interaction also indicates that Auger electrons contribute more than photoelectrons.
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