Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 3, Pages 375-386Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01760a
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Funding
- Nord Pas de Calais region
- Centre National de la Recherche Scientifique (CNRS)
- University Lille 1
- Institut Universitaire de France (IUF)
- European Union through FP7-PEOPLE-IRSES [269009]
- ANR grant [12-BSV5-0016-01]
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The development of non-antibiotic based treatments against bacterial infections by Gram-negative uropathogenic E. coli is a complex task. New strategies to treat such infections are thus urgently needed. This report illustrates the development of pegylated reduced graphene oxide nanoparticles (rGO-PEG) and gold nanorods (Au NRs) coated with rGO-PEG (rGO-PEG-Au NRs) for the selective killing of uropathogenic E. coli UTI89. We took advantage of the excellent light absorption properties of rGO-PEG and Au NR particles in the near-infrared (NIR) region to photothermally kill Gram-negative pathogens up to 99% in 10 min by illumination of solutions containing the bacteria. The rGO-PEG-Au NRs demonstrated better photothermal efficiency towards E. coli than rGO-PEG. Targeted killing of E. coli UTI89 could be achieved with rGO-PEG-Au NRs functionalized with multimeric heptyl alpha-D-mannoside probes. This currently offers a unique biocompatible method for the ablation of pathogens with the opening of probably a new possibility for clinical treatments of patients with urinary infections.
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