Journal
CHEMICAL SCIENCE
Volume 5, Issue 6, Pages 2438-2442Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc00315b
Keywords
-
Categories
Funding
- Institute of Chemical Research of Catalonia (ICIQ) Foundation
- European Research Council (ERC) [278541 - ORGA-NAUT]
- MEC [AP2009-0950]
- ICREA Funding Source: Custom
Ask authors/readers for more resources
We report here the first asymmetric catalytic alkylation of unmodified ketones with alkyl halides. This metal-free approach, which requires light in order to proceed, provides a rare example of highly enantioselective photochemical catalytic processes. An easily available cinchona-based primary amine catalyst guides both the stereoselectivity-defining event and, through the transient formation of photon-absorbing chiral electron donor-acceptor complexes, the photo-activation of the substrates.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available