Journal
CHEMICAL SCIENCE
Volume 5, Issue 7, Pages 2804-2808Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc00198b
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Funding
- National Natural Science Foundation of China [21272093]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20120061120117]
- Innovation Program of the State Key Laboratory of Supramolecular Structure and Materials
- Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University [201301A01]
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We constructed a novel cancer theranostic hybrid platform, based on mesoporous silica-coated gold nanorods (AuNR@MSN) gated by sulfonatocalix[4] arene (SC[4] A) switches, for bio-friendly near-infrared (NIR) light-triggered cargo release in a remote and stepwise fashion. The advantages of supramolecular switches, mesoporous silicas, and AuNRs were combined in one drug delivery system. Mesoporous silicas coated on AuNRs guarantee a high drug payload and can be easily post-functionalized. Significantly, the plasmonic heating from the NIR light-stimulated AuNR cores can decrease the ringstalk binding affinity, leading to the dissociation of SC[4] A rings from the stalks, thus opening the nanovalves and releasing the cargos. The NIR light-responsive mechanized AuNR@MSN offers exciting prospects for non-invasive controlled drug delivery, being more effective and safer than other techniques.
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