Journal
CHEMICAL SCIENCE
Volume 5, Issue 11, Pages 4504-4511Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc01440e
Keywords
-
Categories
Funding
- National Institutes of Health [NIH R01-GM096403]
- NIH [CBI-TB-GM-067543]
Ask authors/readers for more resources
We detail an investigation of a peptide-based catalyst (6) that is effective for the site- (>100 : 1 : 1) and enantioselective epoxidation (86% ee) of farnesol. Studies of the substrate scope exhibited by the catalyst are included, along with an exploration of optimized reaction conditions. Mechanistic studies are reported, including relative rate determinations for the catalyst and propionic acid, a historical perspective, truncation studies, and modeling using NMR data. Our compiled data advances our understanding of the inner workings of a catalyst that was identified through combinatorial means.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available