Journal
CHEMICAL SCIENCE
Volume 5, Issue 8, Pages 3294-3300Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc00789a
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Funding
- Basque Government (Spain)
- Basque government
- MINECO [MAT2010-16171]
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
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A series of functional aliphatic polycarbonates bearing pendant N-heterocycles has been synthesized using a facile and modular synthetic strategy. This allows rapid access to a diverse range of biomimetic nanostructured materials that show promise as non-fouling polyzwitterions, host-defense peptide mimics, and potential drug/gene-delivery vectors, all starting from a common precursor. Preliminary biological data indicate promising non-fouling properties, antimicrobial activity, and negligible toxicity in human cell lines.
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