Journal
CHEMICAL SCIENCE
Volume 5, Issue 6, Pages 2123-2134Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc52768a
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Funding
- NWO VICI grant
- Ministry of Education, Culture and Science [024.001.035]
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Bioorthogonal chemistry allows for selective and efficient modification of biomolecules in their natural environment. Several strategies have been developed over the past years that employ cellular biosynthetic pathways to incorporate the desired functionalities. These moieties in turn efficiently react with exogenously added complementary reaction partners. This field has now moved forward from a conceptual phase to the application of these methodologies in living systems. In this perspective, we highlight recent and exciting developments pertaining to the use of bioorthogonal chemistry in living organisms.
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