Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 37, Pages 7401-7407Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb01169h
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Funding
- Natural Science Foundation of China [NSFC 51403131, 51503130]
- China Postdoctoral Science Foundation Funded Project [2015M570783]
- Young teacher's research startup foundation of Sichuan University [2014SCU11026]
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To construct a smart drug delivery system for simultaneous cellular imaging and cancer therapy, a pH-responsive amphiphilic polymer (MPEG-hyd-TPE) with aggregation-induced emission (AIE) character was designed and successfully synthesized. Polymeric micelles self-assembled from MPEG-hyd-TPE exhibited a significant AIE effect in an aqueous solution with excellent biocompatibility; thus, it can be used for potential bioimaging applications. Moreover, the drug-loaded micelles showed typical pH-regulated drug release behavior. DOX was released more rapidly after the drug-loaded micelles were internalized into cancer cells due to the cleavage of the hydrazone bond under acidic endosomal/lysosomal conditions. In addition, in vitro results demonstrated that the drug-loaded micelles exhibited dose-dependent cytotoxicity to HeLa cells.
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