4.6 Article

Supramolecular assembly of crosslinkable monomers for degradable and fluorescent polymer nanoparticles

Journal

JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 14, Pages 2858-2866

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4tb01880j

Keywords

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Funding

  1. National Natural Science Foundation of China [51373142, 51403176, U1205113]
  2. Scientific and Technical Project of Xiamen [3502Z20130033]
  3. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM065255] Funding Source: NIH RePORTER

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Intermolecular B-N coordination has been recognized as a promising driving force for molecular self-organization. However, direct utilization of this intermolecular interaction as a building bridge for the supramolecular self-assembly of chemical functionalities to form nano-sized architectures remains a daunting challenge. Here, we outline a multiple intermolecular B-N coordination based supramolecular system, where small boronate molecules can be brought together in solution to form nanoparticles with controllable sizes and morphologies. We not only demonstrate the intrinsic switchable fluorescence and the stimuli-responsive capabilities of designed boronate molecules, but also show that the stabilized or surface functionalized nanoparticles are degradable in response to pH and D-glucose and able to retain the fluorescence features of the boronate molecules. Additionally, the degraded nanoparticles can repair themselves through the reformation of B-N coordination.

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