Journal
CHEMICAL SCIENCE
Volume 4, Issue 5, Pages 2201-2208Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc50310k
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Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Grants-in-Aid for Scientific Research [22105002] Funding Source: KAKEN
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A new chelation assisted reaction using a removable 8-aminoquinoline bidentate directing group that permits the ruthenium-catalyzed ortho-C-H bond alkylation of aromatic amides with various alpha,beta-unsaturated ketones under straightforward conditions has been developed. This methodology represents the first efficient utilization of enones in the ortho directed ruthenium-catalyzed addition of C-H bonds to C-C double bonds. The reaction offers a broad scope and a high functional group tolerance.
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