Enantioselective [3+2] annulation via C-H activation between cyclic N-acyl ketimines and 1,3-dienes catalyzed by iridium/chiral diene complexes

Enantioselective [3 + 2] annulation between 1,3-dienes and N-acyl ketimines in situ generated from 3-aryl-3-hydroxyisoindolin-1-ones proceeded via C-H activation to give spiroaminoindane derivatives in high yields with high regio-and enantioselectivity, which is realized by use of an Ir/chiral diene catalyst.