4.8 Article

Luminescent oligonucleotide-based detection of enzymes involved with DNA repair

Journal

CHEMICAL SCIENCE
Volume 4, Issue 10, Pages 3781-3795

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51228b

Keywords

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Funding

  1. Hong Kong Baptist University [FRG2/11-12/009]
  2. Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
  3. Health and Medical Research Fund [HMRF/11101212]
  4. Research Grants Council [HKBU/201811, HKBU/204612]
  5. French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
  6. Science and Technology Development Fund, Macao SAR [001/2012/A]
  7. University of Macau [MYRG091(Y2-L2)-ICMS12-LCH, MYRG121(Y2-L2)-ICMS-12LCH]

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DNA repair processes are responsible for upholding the integrity and stability of genomic DNA. Consequently, the development of analytical assays to monitor enzymes involved with DNA repair pathways is of great interest in a variety of disciplines, including biochemistry, cell biology and biotechnology. In this perspective, we highlight examples of the development of luminescent assays for the detection of enzymes involved with DNA repair that have been reported in the last several years.

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