Journal
CHEMICAL SCIENCE
Volume 4, Issue 2, Pages 764-769Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc21850j
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Funding
- EPSRC [EP/F069685/1]
- Royal Society
- BP Endowment
- Engineering and Physical Sciences Research Council [EP/F069685/1] Funding Source: researchfish
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The flow of information between chemical and biological research can present a bottleneck in pharmaceutical research. Tools that bridge these disciplines and aid information exchange have therefore clear value. Over the last few years, both synthetic chemistry and biological screening have benefited from automation, and a seamless chemistry-biology interface is now possible. We report here on the use of flow processes to perform synthesis and biological evaluation in an integrated manner. As proof of concept, a flow synthesis of a series of imidazo[1,2-a] pyridines, including zolpidem and alpidem, was developed and connected to a Frontal Affinity Chromatography screening assay to investigate their interaction with Human Serum Albumin (HSA).
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