Journal
CHEMICAL SCIENCE
Volume 4, Issue 7, Pages 2886-2891Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc50891a
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Funding
- Ministry of Education, Culture and Science [024.001.035]
- ERC [204554 - SupraChemBio]
- [CTMM - 03O-201 Mammoth]
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Dynamic protein assembly along supramolecular columnar polymers has been achieved through the site-specific covalent attachment of different SNAP-tag fusion proteins to self-assembled benzylguanine-decorated discotics. The self-assembly of monovalent discotics into supramolecular polymers creates a multivalent, bio-orthogonal and self-regulating framework for protein assembly. The intrinsic reversibility of supramolecular interactions results in reorganization and exchange of building blocks allowing for dynamic intermixing of protein-functionalized discotics between different self-assembled polymers, leading to self-optimization of protein arrangement and distance as evidenced by efficient energy transfer between fluorescent proteins.
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