Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 12, Pages 2560-2571Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00235d
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Funding
- CNRS
- University of Strasbourg
- association L'Alsace contre le cancer
- European Union (European Regional Development Fund - ERDF)
- Region Alsace
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In bioimaging, targeting allows refining the diagnosis by improving the sensitivity and especially the specificity for an earlier diagnosis. Two 111In-radiolabeled dendritic nanoprobes (DPs) (In-111-2, In-111-3) and their model counterparts (In-111-1, In-111-4) are designed and assessed for in vitro and in vivo tumor targeting efficiency in a murine melanoma models. Tumor uptake is correlated to dendrimer multivalency and reaches values as high as 12.7 +/- 1.6% ID g(-1) at 4 h post intravenous injection for In-111-3 vs. 1.5 +/- 0.5% ID g(-1) for the unfunctionalized DP, and over 11% ID g(-1) for any tumor weight whatsoever.
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