Journal
CHEMICAL SCIENCE
Volume 3, Issue 9, Pages 2700-2707Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc20392h
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Funding
- UK Engineering and Physical Science Research Council [EP/F063733/1]
- Royal Society/Wolfson Foundation
- Engineering and Physical Sciences Research Council [EP/F063733/1] Funding Source: researchfish
- EPSRC [EP/F063733/1] Funding Source: UKRI
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Designed to remove some of the mystery surrounding mixed-metal TMP (2,2,6,6-tetramethylpiperidide) metallating reagents, this study examines in detail LiCd(TMP)(3)'' in its own right. Previously established as an excellent cadmating'' (Cd-H exchange) reagent towards a wide variety of aromatic substrates, LiCd(TMP)(3)'' has been investigated by H-1, C-13 and Cd-113 NMR studies as well as by DOSY NMR spectroscopy. This evidence puts a question mark against its ate formulation implying it exists in THF solution as two independent homometallic amides. Exploring the reactivity of LiCd(TMP)(3)'' with anisole as a test substrate, both experimentally by NMR studies and theoretically by DFT studies suggests a two-step lithiation/transmetallation process in which the initially formed ortho-lithiated species undergoes a reaction with Cd(TMP)(2) to form new Cd-C and Li-N bonds. For completeness, the homometallic cadmium component Cd(TMP)(2) has been comprehensively characterised for the first time including a crystal structure determination revealing a near-linear N-Cd-N arrangement.
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