Journal
CHEMICAL SCIENCE
Volume 3, Issue 10, Pages 3088-3092Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc20835k
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Funding
- NIH [GM069559]
- Office of Energy Research
- Office of Basic Energy Sciences
- Chemical Sciences Division
- U.S. Department of Energy [DE-AC02-05CH11231]
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We herein report the Rh(III)-catalyzed C-H bond activation and addition of benzimidates to aldehydes to afford biologically important phthalides in a single step. The imidate is a novel and unexplored directing group that not only enables C-H bond activation and addition to aldehydes, but also serves to capture the reversibly formed alcohol intermediate. The reaction shows broad scope with a high level of functional group compatibility and is applicable to both aromatic and aliphatic aldehydes.
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