Journal
CHEMICAL SCIENCE
Volume 3, Issue 12, Pages 3463-3467Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sc21041j
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Funding
- National Natural Science Foundation of China [20932002, 21172076]
- National Basic Research Program of China (973 Program) [2011CB808600]
- Guangdong Natural Science Foundation [10351064101000000]
- China Postdoctoral Science Foundation [2011M501318]
- Fundamental Research Funds for the Central Universities [2010ZP0003, 2012ZB0011]
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A robust and regioselective copper(II)-catalyzed cycloaddition of internal alkynes and nitrites providing an effective access to oxazole fragments is reported herein. Water substantially participated in this reaction. Control experiments proposed that this transformation may proceed via an enamide intermediate. This strategy enables the preparation of the core structure of a COX-2 inhibitor.
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