Journal
CHEMICAL SCIENCE
Volume 2, Issue 4, Pages 770-775Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sc00565g
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Funding
- Deutsche Forschungsgemeinschaft [SFB 765]
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A wide range of multivalent scaffolds was assembled by using only five different PNA oligomers and various DNA templates. The flexibility of the PNA-DNA duplexes could be increased by introducing nick-sites and partially unpaired regions, as confirmed by MD simulations. The self-organized glyco-assemblies were used in a spatial screening of accessible carbohydrate binding sites in the Erythrina cristagalli lectin (ECL). This systematic investigation revealed a distance dependence which is in agreement with the crystal structure analysis.
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