Journal
CHEMICAL SCIENCE
Volume 1, Issue 2, Pages 206-209Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sc00125b
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Funding
- Intelligent Cosmos Foundation
- Japan Science and Technology Agency (JST)
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Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.
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