Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 30, Pages 6239-6247Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb00833f
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Funding
- European Commission (MULTIFUN) [262943]
- Comunidad de Madrid NANOFRONTMAG-CM project [S2013/MIT-2850]
- Spanish Ministry of Economy and Competitiveness [MAT2013-47395-C4-3-R]
- European COST Action [TD1402]
- Ramon y Cajal subprogram [RYC-2011-09617]
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In recent years, magnetic nanoparticles have been widely investigated due to their potential in biomedical applications. For successful in vivo applications, magnetic nanoparticles must satisfy several requirements such as biocompatibility, invisibility to the immune system, high colloidal stability in biological fluids, and long blood circulation times. In this study, we have developed a formulation in which the magnetic nanoparticles are coated with bovine serum albumin to provide enhanced colloidal stability in biological fluids preserving their magnetic properties. In addition, the nanoparticles carry a chemotherapeutic drug, showing their potential as drug delivery systems. Our results reveal the influence of protein adsorption on the colloidal stability and the dynamical magnetic response of functionalized magnetic nanoparticles. Moreover, cellular internalization and in vitro cytotoxic activity in Panc-1 pancreatic cancer cells reveal enhanced cellular internalization, successful intracellular drug delivery, and efficient anticancer activity.
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