Journal
JOURNAL OF BREATH RESEARCH
Volume 8, Issue 3, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1752-7155/8/3/037104
Keywords
aldehydes; breath analysis; SIFT-MS
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Funding
- Imperial National Institute for Health Research Biomedical Research Centre
- Rosetrees Trust
- Leicester Foundation
- Rosetrees Trust [M261-CD1] Funding Source: researchfish
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Aldehydes have attracted great scientific and clinical interest as potential disease biomarkers. We have investigated selected ion flow tube-mass spectrometry (SIFT-MS) in detecting and quantifying C3 to C10 saturated aldehydes (propanal, butanal, pentanal, hexanal, heptanal, octanal, nonanal and decanal) from the exhaled breath of 26 healthy human volunteers. To assess the reliability of the Nalophan (R) bag sampling method employed, the water level in the breath sample was measured up to 4 h after collection and showed no significant degradation. Propanal was found to be the most abundant aldehyde in the exhaled breath of healthy volunteers. For the C4-C10 aldehydes, their median concentrations were all less than 3 ppbv, demonstrating only trace quantities are present in the exhaled breath of the 26 healthy volunteers.
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