Journal
JOURNAL OF BREATH RESEARCH
Volume 3, Issue 2, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1752-7155/3/2/027004
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Funding
- Center of Excellence in Medicine and IT (CEMIT
- formerly Kompetenzzentrum Medizin Tirol, KMT, Innsbruck, Austria)
- EU
- Austrian Research Promotion Agency (FFG)
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We report on on-line breath gas analysis with a new type of analytical instrument, which represents the next generation of proton-transfer-reaction mass spectrometers. This time-of-flight mass spectrometer in combination with the soft proton-transfer-reaction ionization (PTR-TOF) offers numerous advantages for the sensitive detection of volatile organic compounds and overcomes several limitations. First, a time-of-flight instrument allows for a measurement of a complete mass spectrum within a fraction of a second. Second, a high mass resolving power enables the separation of isobaric molecules and the identification of their chemical composition. We present the first on-line breath measurements with a PTR-TOF and demonstrate the advantages for on-line breath analysis. In combination with buffered end-tidal (BET) sampling, we obtain a complete mass spectrum up to 320 Th within one exhalation with a signal-to-noise ratio sufficient to measure down to pptv levels. We exploit the high mass resolving power to identify the main components in the breath composition of several healthy volunteers.
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