Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 38, Pages 7494-7498Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb01738f
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Funding
- 973 program [2013CB127603]
- National Science Foundation of China [21174012, 51221002, 21574009]
- Beijing Natural Science Foundation [2142026]
- Innovation and Promotion Project of Beijing University of Chemical Technology
- Chinese Universities Scientific Fund [2015NX001, 2015QC094]
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A novel amphiphilic squarylium indocyanine (LysoCy) is reported for remarkable lysosome tracking in live cells. LysoCy performs as a promising lysosome tracker with low cytotoxicity, a strong binding affinity and clear subcellular labelling. The long-term dynamics of lysosomes can be revealed by LysoCy for up to 2 days of culture, while the working duration of commercial dye is no longer than 1 hour. Our work provides a good alternative tool for long-term live cell imaging.
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