Journal
JOURNAL OF MATERIALS CHEMISTRY B
Volume 3, Issue 38, Pages 7577-7584Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5tb01056j
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Funding
- National Natural Science Foundation of China [51373124, 21007049]
- Youth Chen-Guang Project of Wuhan Bureau of Science and Technology [2014070404010196]
- Program for New Century Excellent Talents in University [NECT-10-0618]
- Special Fund for Environmental Protection in the Public Interest [2013467064]
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In this study, we report a single electrodeposition process to fabricate multilayered chitosan/layered double hydroxides (LDHs) hybrid hydrogels for stimuli responsive protein release. LDHs nanoplatelets with a regular hexagonal shape were synthesized by a hydrothermal method, and a model protein, insulin, was adsorbed on the surface of the LDHs (INS-LDHs) via electrostatic interactions. The insulin loading ratio could reach 20% (w/w); the INS-LDHs were characterized by energy dispersive spectrometry (EDS), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TG) and zeta potential measurements. Co-electrodeposition of chitosan and INS-LDHs generated an inorganic and organic composite hydrogel with a multilayered structure, as revealed by scanning electron microscopy (SEM). The hybrid hydrogel dramatically reduced the burst release of insulin from INS-LDHs. Notably, the release of insulin was sensitive to the presence of anions, pH, and external potentials. These results suggest that co-electrodeposition of a stimuli-responsive polymer and nanoplatelets is an alternative and facile method to construct hierarchically structured hybrid hydrogels and demonstrate the great potential of the multilayered structure in drug delivery.
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